Trials for Cerebellar Ataxias: From Cellular Models to...

Trials for Cerebellar Ataxias: From Cellular Models to Human Therapies

Bing-wen Soong, Mario Manto, Alexis Brice, Stefan M. Pulst
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Despite the critical importance of the cerebellum in brain function, the scientific community still lacks effective treatments for most cerebellar ataxias.  This book provides  a link between the pathogenesis and therapies of cerebellar ataxias while also providing a comprehensive assessment of the preclinical and clinical trials dedicated to cerebellar ataxias over the past 20 years of progress.  This is the first book fully dedicated to the trials and therapies of these disorders. It is a truly authoritative and comprehensive reference, and comes at a time of major advances in genetic tools and neuroimaging assessments.  The coverage begins by laying a foundation of the basic science of the cerebellum and ataxias, proceeds to discuss biomarkers and the tools of trials, offers guidelines on conducting trials,  and then explores the full range of therapeutics and their trials, including gene therapy and cell transplantation. The authors are top experts on cerebellar research and the contributing authors have all made seminal contributions in the field.
年:
2023
出版商:
Springer
語言:
english
頁數:
716
ISBN 10:
3031243447
ISBN 13:
9783031243448
系列:
Contemporary Clinical Neuroscience
文件:
PDF, 28.05 MB
IPFS:
CID , CID Blake2b
english, 2023
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